In Vitro Glucuronidation of ∆-Tetra- hydrocannabinol-D3 by UDP-Gluc- uronosyl-Transferases detected using LC/MS-MS
نویسندگان
چکیده
From several studies it has been shown, that ∆-tetrahydrocannabinolglucuronide is a phase II metabolite of ∆-tetrahydrocannabinol (THC) formed and excreted in urine in humans [1]. There is not much known either about the extent of glucuronidation in the metabolic degradation and elimination of ∆tetrahydrocannabinol (THC) or about which one of the enzymes of the UDPGlucuronosyl-Transferase (UGT) family is forming the THC-conjugate. Therefore, we studied seven commercially available variants of the UGTs regarding their enzymatic activity to THC-D3 (Figure 1).
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